Ponatinib interacts with 566 known drugs, 5 disease interactions, and 1 alcohol/food interaction. It is a substrate and inhibitor of P-glycoprotein and BCRP, so use with strong transporters should be avoided. It is primarily metabolized by the CYP3A4 enzyme. https://medsforcancer.com/product/ponaxen-15-45mg-ponatinib/