At this time, there are two kinds of research on itaconate: Irg1−/− macrophages as well as regulatory effect of itaconate derivatives. These two success have been complementary and exposed which the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription component 3 (ATF3) https://johnnyjiewq.mybuzzblog.com/9335617/the-2-minute-rule-for-recombinant-his