Pentobarbital decreases levels of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Prevent Except the coadministration outweighs the probable threat of ponatinib underexposure; monitor for signs of diminished efficacy. pentobarbital will lower the extent or influence of ripretinib by influencing hepatic/intestinal enzyme CYP3A4 ... https://isnembutalabarbiturate10864.ja-blog.com/31024596/5-simple-statements-about-what-type-of-drug-is-nembutal-explained