Below problems of low CB1R density, THC antagonises endogenous agonists possessing increased receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which may give extra oblique routes for altering dopamine transmission21. Also, THC has psychoactive metabolites with CB1R affinity, further more complicating the analyses of receptor binding studies22. Marinol, https://titusixdjo.topbloghub.com/39390564/the-best-side-of-edibles